Medically reviewed by Sanjai Sinha, MD. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (2021). Bring someone with you to your appointment if doing so will help you feel more comfortable. (To learn more, see the Precautions for Prolia section below.). Youll receive Prolia doses from a healthcare professional. Try to avoid being around people who are sick. Some rare side effects of Prolia can be serious and need medical attention. Youll receive Prolia doses from a healthcare professional. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. For more information, you can refer to the drugs prescribing information. These include osteonecrosis of the jawbone. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. So be sure to tell your doctor about all your health conditions before taking Prolia. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. Osteoporosis medications and medication-related osteonecrosis of the jaw. You may need to have a dental exam before you begin treatment with Prolia. Talk with your doctor about your health history and discuss your risks with Prolia treatment. If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. (2022). Yes, if recommended by your doctor, you can stop taking Prolia. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. Common interactions include nausea among females and fatigue among males. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Mild side effects can occur with Prolia use. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. With osteopenia, your bone mineral density (BMD) is lower than usual. How long will I need to keep taking Prolia? Prolia is an injection prescribed for certain adults with osteoporosis, which The study uses data from the FDA. This is because your body doesnt make enough bone, or it loses bone faster than it makes new bone. You should talk with your doctor if you develop any mild side effects that concern you. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. The conditions and factors to consider include: Upcoming dental procedures. It can have some side effects, but these may depend on who uses it. It is important not to miss your dose. Learn about the highest quality calcium supplements here. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Also describe any vitamins, herbs, or supplements you use. But if they become bothersome, talk with your doctor or pharmacist. You may also want to do some research on your own. High cholesterol itself doesnt cause any symptoms. When estrogen levels drop, your risk of osteoporosis goes up. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. You can learn more about how we ensure our content is accurate and current by reading our. Be sure to talk with your doctor about which medication is right for you. Do not shake the prefilled syringe. Prolia works by blocking osteoclasts (certain bone cells) from breaking down bone tissue in your body. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. You may need to go to the hospital for treatment. People need calcium for bone health and other functions. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. However, drinking too much alcohol may raise your risk of falling. * For more information about this side effect, see Side effect specifics below. Do not stop, skip or delay taking Prolia without first talking with your doctor. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. To learn more about this side effect, see Side effect specifics below. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Follow your doctor's instructions. What do I need to be aware of if I need a tooth extraction while Im using Prolia? Prolia may lower the calcium levels in your blood. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. They will also explain how much youll be given and how often. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. They may give you tips on managing a body weight thats healthy for you. Nausea can sometimes be a symptom of severe constipation. You may report side effects to FDA at 1-800-FDA-1088. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. With arthritis, you have pain and inflammation of your joints. Tell your doctor about all other medicines you use. Doing so will help to prevent dental problems. Talk with them about your health and any concerns you have about Prolia and its effects. With low BMD your bone tissues have less mineral, which means they become weaker. For more information about how Prolia and Zometa compare with each other, see this article. Different individuals may respond to medication in different ways. The risk is real, but rare. Another common osteoporosis medication is denosumab (Prolia, Xgeva). WebDrug interactions are reported among people who take Prolia and Calcium. Serious infections may occur during treatment with Prolia. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Patients in the study may take other drugs besides Prolia and Calcium. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. This aids in keeping your calcium level within the recommended range. Learn more about some of the side effects Prolia may cause. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. This may help to protect healthy cells from damage. Heres a short list of some of the mild side effects that Prolia can cause. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. Patient testimonials represent individual experiences with Prolia. But if you think youre having a medical emergency, call 911 or your local emergency number. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. Healthline Media does not provide medical advice, diagnosis, or treatment. Store in the original container away from heat and light. 2023 Healthline Media LLC. But certain choices and habits accelerate the process. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. Theyll also discuss with you how to lower your risk for fractures by adding other treatments or making certain lifestyle or diet choices. There are no known interactions with Prolia and other medications, supplements, or other products. Brush and floss your teeth as directed. 8,432 people who take Prolia and Calcium together, and have interactions are studied. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. Prolia is meant to be used in combination with calcium and vitamin D supplements. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Its important to tell your doctor if you have serious or ongoing side effects. Some examples of these treatments include: Talk with your doctor about other drugs you may need to take with Prolia. But, in some cases, alcohol can affect your balance and increase your risk for falls. Although its rare, your doctor may give you the option to self-inject Prolia at home. * Sex and gender exist on spectrums. Learn how to increase or maintain bone density here. (A placebo is a treatment with no active drug.). Prolia can cause both mild and serious side effects. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. Tell your doctor if you become pregnant. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. How long will the side effects of Prolia last? But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. For more information about how these medications compare with each other, ask your doctor. What osteoporosis medications are there, and what side effects do they have? Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments Do not stop using this medicine without first talking to your doctor. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. The drug may increase the risk of pregnancy loss. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. Talk with your doctor about the best options for treating your condition. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. Tell your doctor if youd like to know more about these drugs. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. Learn strategies you can use today. * Approximation only. Prolia is a monoclonal antibody. This makes your bones weak and increases your risk for bone fractures or breaks. Do not use denosumab if you are pregnant. They can give you more details about this possible side effect and suggest ways to manage it. This medicine may cause jaw bone problems (osteonecrosis). According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Theyre commonly used to treat osteoporosis. Prolia contains the active ingredient denosumab. Prolia can also increase this risk. Its a, Forteos active ingredient is teriparatide. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. Tell them if you have any scheduled dental work coming up. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. This information is intended only for U.S. healthcare professionals. This medication guide provides information about the Prolia brand of denosumab. This list doesnt include all possible mild side effects of the drug. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. Thyroid or parathyroid surgery. Talk with your doctor about the risks of using this drug during pregnancy. You may want to know how Prolia compares to the medication Tymlos. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Can you drink alcohol while taking Prolia? Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. They can also happen if you have certain conditions or if you take certain medications. You should also ask your doctor if Prolia is safe for you if you have or have had: Additionally, let your doctor know if youre pregnant or breastfeeding. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. * Sex and gender exist on spectrums. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Serious skin infections may occur, but are uncommon If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. And theyll recommend if its the best option for your condition. Prolia may cause several side effects. Any advice? (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) Tell your doctor if you become pregnant. Brush and floss your teeth regularly. What should I know about Prolia vs. Zometa? Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. If you have serious side effects from Prolia, call your doctor right away. You may wonder how Prolia compares with the alternative drug Reclast. Learn about the different options, including the benefits of each and any potential side, A FRAX score can help predict the risk of fractures in people with osteoporosis. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. Costs of prescription drugs can vary depending on many factors. Prolia is usually given once every 6 months. And if you have osteoporosis, falling could increase your risk of fractures.