does ashwagandha interact with medications

Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. Certain antidepressants may not be compatible with herbs or other natural ingredients in these products. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. Feel free to send him an email at Hello@HelloPharmacist.com! Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. 8-16-1995;95(1-2):189-193. Supplements That Are Similar to Ashwagandha. Complement Ther Med 2016 Aug;27:25-9.View abstract. Cooley K, Szczurko O, Perri D, et al. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). Hidese S, Ogawa S, Ota M, et al. I recommend taking it at bedtime for a better night's rest or you can take it during the day. ashwagandha and guggul used for thyroid conditions and find out if they are beneficial. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Created for people with ongoing healthcare needs but benefits everyone. Information from this source is evidence-based and objective, and without commercial influence. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Several supplements and herbs may act similarly to ashwagandha. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. Acta Nerv Super 1990;32(1):1-5. 2003;19(3):211-222. Ashwagandha interferes with immunoassay measurements of digoxin, a medication primarily used for treating congestive heart failure and abnormal heart rhythms. View abstract. View abstract. Doctors prescribe immunosuppressants for people with conditions such as rheumatoid arthritis, psoriasis and ulcerative colitis, and to prevent rejection of organ transplants. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. 2008;6:14. Is Fish Oil Dangerous With Antidepressants? Ashwagandha might lower blood sugar levels. Additionally, ashwagandha may increase testosterone levels in the body. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. . Evid Based Complement Alternat Med. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. View abstract. Other essential vitamins and minerals may also be helpful in treating depression. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. It may also interact with other herbs, supplements, and even foods. The combination could result in excess thyroid hormone in the body, which has many negative effects. 2021 Nov 25;13(2):100510. Hi, I was recommended to take ashwagandha. Can You Take A Z-Pak If You Have A Penicillin Allergy? The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. metoprolol, nebivolol, propranolol), Diuretics (e.g. View abstract. Pharmacol Biochem.Behav 2003;75(3):547-555. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. Ashwagandha can increase the activity of the immune system. It is just a general precaution that ashwagandha may decrease blood sugar. This information does not contain all possible interactions or adverse effects. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. Some of the more compelling potential uses of ashwagandha are outlined below. View abstract. Sud Khyati S, Thaker B. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Chitre D, Nadkarni S, Jagtap N, et al. The average vitamin or mineral should not affect your antidepressant's functionality or your health. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. 1965;9(3):127-136. Jardiance,Farxiga, Invokana), ACE-Inhibitors (e.g. 2017 Jan;22(1):96-106 View abstract. This dosing has also been associated with improvements in memory. Bjrnsson HK, Bjrnsson ES, Avula B, et al. 2013;2013:571420. Medically reviewed by Drugs.com. View abstract. 2020;72:28-36. Hence, be cautious if taking these medications and want to take Ashwagandha also. Liver Int. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. In rare cases, ashwagandha may cause liver damage. blood glucose). Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. hydrochlorothiazide, spironolactone, chlorthalidone). There is animal research that suggests that ashwagandha may lower systolic and diastolic blood pressure, putting people who take blood pressure-lowering medication at risk for hypotension,. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. J R Coll Physicians Edinb. In the study, no adverse events were reported by participants who took the herb. Altern Med Rev 2000;5:334-46. View abstract. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. Is It Safe To Take Keflex (Cephalexin) With Birth Control? Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Ashwagandha may lower blood sugar (i.e. 2021;2:72-81. doi:10.1016/j.crtox.2021.02.002. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Ashwagandha has been traditionally used for anxiety, insomnia, aging, and other conditions that may be exacerbated by stress. View abstract. View abstract. Phytotherapy Research 1989;3(5):201-206. People taking certain medications may need to avoid using ashwagandha. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Third-party agencies like these confirm that supplements actually contain what they say they do, but they do not approve medical claims. National Center for Complementary and Integrative Health. Of note, the benefits were strongest in those who took at least 600 milligrams per day of ashwagandha for at least eight weeks. What about black My Dr. put me on 500mg of cephalexin 3 times a day and 150mg of fluconazole. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. Ahmad MK, Mahdi AA, Shukla KK, et al. The Journal of Psychiatry study reported that omega-3 fats and vitamin D are the two essential nutrients that are most likely to help reduce depression symptoms. Use birth control you can trust while taking this product. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Indian J Med Res 2015 Jan;141(1):100-6. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. Herbs like Ashwagandha are known to interact with SSRI and other medicines. View abstract. Ancient herb eases stress, boosts memory, and may help you lose weight. Often, herbs and supplements come with a risk of side effects. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Because ashwagandha supports immune system function, it might interact with medications designed to reduce immune system activity, known as immunosuppressants, according to the University of Maryland Medical Center. Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. Curr Res Toxicol. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Learn which supplements can interact with thyroid hormone medications like levothyroxine (Synthroid), thyroid hormone levels, and laboratory tests. . Biomed Res Int 2015;2015:284154.View abstract. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. 2009;15(4):423-430. St. John's wort can cause a buildup of serotonin in the body when taken with antidepressants. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. However, scientific evidence supporting these and other uses is poor. Read more: How Vegans Can Get All Their Nutrients (Without Taking Supplements). Moreover, researchers also noted several limitations of the studies included, such as the varying methods used to assess sleep quantity and quality. Herbal supplements, like St. John's wort or garcinia cambogia, are much more likely to affect the functionality of your antidepressants compared to vitamins or mineral tablets. They also are not very good drugs, because they have multiple potentially . Antioxidants (Basel). Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. View abstract. Food Chem.Toxicol. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. View abstract. 2011;68(1):3-8. Indian J Exp Biol 2000;38:607-9. View abstract. View abstract. View abstract. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Which is why it might lead to sleepiness and drowsiness with medications such as Wellburtin. If possible, choose an ashwagandha supplement that has been reviewed and approved by a third-party agency, like USP, NSF International, or ConsumerLab. View abstract. Ashwagandha has no known moderate interactions with any drugs. View abstract. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. View abstract. View abstract. J Clin Med 2021;10(16):3644. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. Int.J.Crude Drug Res. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Health Sci Rep 2022;5(4):e741. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. J Ethnopharmacol 1998;62:209-14. J Altern Complement Med. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Historically, ashwagandha has been thought of as a possible stimulant for athletics since the ancient medical system. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. It may also interact with other herbs, supplements, and even foods. Read our. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. J Ayurveda Integr Med. levothyroxine, desiccated thyroid) could potentially increase thyroid hormone levels too much, increasing the risk of side effects. Effect of Ashwagandha (Withania somnifera Dunal) on the process of ageing on human volunteers. Xanax. Some people may need to avoid taking Ashwagandha, however, including those who: Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. Mental health statistics show between 3 and 5 percent of adults live with a depressive disorder globally, according to a January 2014 study in Depression and Anxiety. Ashwagandha supplements come in various forms, including capsules, gummies, caplets, liquid extracts, and powders. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. Ashwagandha may interact with various medications. DISCLAIMER: Currently this does not check for drug . Take extra care if you are at a high risk for infection. View abstract. A variety of of vitamins and nutritional supplements have been shown to help treat depression. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Gastrointestinal side effects including nausea, vomiting and diarrhoea. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. Some people should avoid using ashwagandha due to safety concerns. 1998;60(2):173-178. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. low blood sugar). J.Transl.Med. Take extra care if you are taking iron supplements. View abstract. 2019;11(12):e6466. Drug Metabol.Drug Interact. Another traditional use of ashwagandha in Ayurveda is for memory issues. View abstract. Now, most studies suggest that ashwagandha doesn't have significant blood pressure lowering effects, so the interaction here is thought to be relatively mild. View abstract. Go to the ER right away. There are a variety of essential vitamins and minerals you should consume on a daily basis. However, many studies supporting the use of ashwagandha are small or poorly designed. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. View abstract. Although ashwagandha is one of the more well-studied herbals on the market, there have not been extensive drug-interaction studies with it. In comparison, a small human trial published in 2022 showed additional proof that ashwagandha may be helpful for people living with anxiety. Are there any side effects of ashwagandha? They should also be kept from direct sunlight and stored in their original bottle or container. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. Do not use this product if you are pregnant or plan to become pregnant soon. View abstract. The April 2008 issue of "Therapeutic Drug Monitoring" notes that some herbal products interfere with methodology used to measure drug levels in a patient's bloodstream. Phytother Res 2022. . Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . Skinmed. Indian J Exp Biol. Guerrero FA, Medina GM. Ashwagandha has mild interactions with at least 29 different drugs. Indian J Physiol Pharmacol. View abstract. Gopal S, Ajgaonkar A, Kanchi P, et al. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Dietary supplements: what you need to know. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? I was told that I had an allergic reaction to penicillin when I was a child. Thyroid Suppression Test. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Acta Oncol. 2012;10(1):48-9. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. View abstract. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Take extra care if you are taking drugs to help with your thyroid. View abstract. Durg S, Bavage S, Shivaram SB. View abstract. This is according to a recent review of case studies of liver damage caused by ashwagandha. Nonetheless, additional large-scale, long-term studies would strengthen these findings. Indian J Exp Biol. View abstract. Be sure to let your doctor know if you plan on adding ashwagandha to your medication list so you can be appropriately monitored. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Am J Drug Alcohol Abuse 2009;35(1):1-11. View abstract. Sedatives: Since ashwagandha can both energize and induce restorative sleep, it might negate or amplify the effect of other sedative drugs, especially the benzodiazepines. Hydroxyzine has moderate interactions with at least 207 different drugs. Withania somnifera extract. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. J Obstet Gynaecol Res 2021. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. J Med Food 2022. View abstract. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. Read More. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. This herb used in alternative medicine may help reduce stress. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. Hypothyroidism, After Thyroid Removal. Taking ashwagandha along with these medications might decrease the effects of these medications. J Neurol Sci 2000;176:124-7. View abstract. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Consult your doctor before taking ashwagandha if you use digoxin. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. Unlike people taking SSRIs who can consume most foods without issue, people taking MAOIs need to avoid foods rich in tyramine, a nonessential amino acid. 1998;20(1):191-198. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Brain Behav. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. Do note that ashwagandha itself does not . Staff, Cotellic With Turmeric And Black Pepper Interaction. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Complement Ther Med. A systematic review and meta-analysis of randomized controlled trials. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Take extra care if you are using drugs to help you relax or sleep. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. This product may interfere with some lab tests. View abstract. Deshpande A, Irani N, Balkrishnan R, Benny IR. Ashwagandha has mild interactions with at least 29 different drugs. Its effects on arterial blood pressure in anaesthetized dogs. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement.
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